LC50 for marine water algae provides substance information on the substance’s lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Otherwise data is displayed as provided by the registrant(s). If so, the pressure data provided is not processed for the Brief Profile. Manufacturers and importers can provide the following information in the registration dossier: Hazard for Air provides information on the substance’s hazard assessment conclusion related to air. Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. The PIC regulatory processes identified for the Brief Profile are: The ’About this substance’ section provides an overview of the volume in which this substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). InChI is an abbreviated name for IUPAC International Chemical Identifier, a chemical identifier developed and supported by the InChI Trust. If more than one type of substance is registered, both types will be displayed. The Agency thus cannot guarantee the correctness of the information displayed. Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food. Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Readily biodegradable but failing the 10-day window. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). The total number of non-confidential registered compositions submitted in REACH dossiers are displayed here. Biodegradation in water provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options: This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance. PBT properties are derived from REACH registered substances dossiers. For a detailed overview on identified uses and environmental releases, please consult the detailed information from the registration dossiers. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. The ‘Scientific properties’ section gives an overview of summarised scientific data from registered dossiers. Pre-registration allows companies to continue manufacturing and importing their. Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. If no data is available in the registered substance dossiers, this will be indicated by a notification stating ‘Data not provided by the registrant’. This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms. If so, the data provided is not processed for the Brief Profile. The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. VW denotes the form in which the substance is produced or placed on the market. Information in the guidance on safe use section consists of recommendations by a substance registrant(s) on the proper use of the substance in various situations. The POPs regulatory processes identified for the Brief Profile are: Classification, Labelling and Packaging (CLP)The CLP Regulation (1272/2008) entered into force on 20 January 2009. EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration. Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C. This section displays the values related to genetic toxicity from all registered dossiers for the substance. It is formed upon oxidation of fats (hence its name, from Greek pimele, “fat”) and occurs in the urine of herbivores. This section summarises the values related to the screening tests for biodegradation in water from all registered dossiers for the substance. After evaluation, proposals may be made for further regulatory action regarding the substance. Values are displayed in milligram per litre. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). 2020 © Copyrights BroadPharm. Units and data are normalised when possible and therefore the unit of measure/order of magnitude in the Brief Profile data may not correspond exactly to the one in the registered dossier. The percentage is based on the count of values provided. Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. Data is generally displayed in milligrams per kilogram bodyweight per day. Candidate List – indicates if the substance is included in the candidate list of substances of very high concern (SVHCs). Nat Rev Drug Discov. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Release to the environment of this substance can occur from industrial use: manufacturing of the substance. EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH). EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes skin irritation. LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre. Please note: The icons in this section are only meant as visual indicators to help communicate information about the abovementioned critical properties. Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C. For accuracy reasons, substance manufacturers and importers are responsible for consulting official sources. Data is generally displayed in milligram per kilo bodyweight. This section summarises the water solubility values from all registered dossiers for the substance. Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C. Autoflammability / Self-ignition provides substance information on the substance’s self-ignition temperature in °C  at a pressure measured in Pascal. Harmonised C&L– indicates if a European Union harmonised classifications and labelling has been assigned to the substance according to Annex VI to CLP and subsequent ATPs. Annex V – indicates if the substance is prohibited from export. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. Long-term EC10 or LC10 or NOEC for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil dwelling arthropods in the test, or the no observed effect concentration for soil dwelling arthropods. Percentage distribution in the Media displays the values attributed by the registrants to the following options: For this endpoint registrants do not provide summaries that are processable for the Brief Profile.Type of study provided. 'IUPAC name' is the generic field by which substance names are provided in various data submission tools. Registrants can identify the origin of their substance as being: If more than one type of substance is registered, both types will be displayed. Registrants can choose from the following picklist endpoint conclusions/effect levels: Eye irritation provides substance information on the substance’s irritation effect on the eye. Guidance on the safe use of the substance provided by manufacturers and importers of this substance. This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance. Other names gives any names of any other type, such as common names, synonyms and acronyms. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). No data available: testing technically not feasible. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. This section summarises the pH values from all registered dossiers for the substance. Processable data for summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. If more than one numerical result is available per endpoint, the range of results (min-max, RANGE method) will be displayed. Information on this page: Mass spectrum (electron ionization) References; Notes Substance Name: Pimelic acid RN: 111-16-0 UNII: BZQ96WX25F InChIKey: WLJVNTCWHIRURA-UHFFFAOYSA-N Applicant’s summary and conclusion – Interpretation of results. Solubility in organic solvents at 20°C provides substance information on the substance solubility in organic solvents in gram per litre at a temperature of 20°C. Half-life in air provides substance information on the substance’s dissipation half-life in air in seconds/minutes/hours/days/weeks/months/years. Data is generally displayed in milligrams per litre. This section summarises the values related to long term toxicity to fish from all registered dossiers for the substance. Nat Rev Drug Discov. If so, the data provided is not processed in the Brief Profile. Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions: Prioritisation of display occurs based on the order above. Data is generally displayed in milligram per litre or molar per litre. EC50/LC50 for microorganisms provides substance information on the substance’s effect concentration or lethal concentration for 50% of the microorganisms in the test, generally displayed in milligram per litre. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). The following properties have been highlighted as critical: The substance properties displayed in this section (with the exception of PBT properties) are derived from harmonised classification and labelling (CLH) and/or REACH registered dossier information. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. While it is present in the final substance, it was not intentionally added. Praesent et nulla orci. If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method). This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. 1.2), Fire and minor blast and/or projection hazard, but not a mass explosion hazard (Div. Data is generally standardised and displayed in in milligram per kilo of food. The availability of additional data beyond the five results displayed is indicated by (…). This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. Note: Registrants can also select ‘other’ as the unit of measure. Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C. Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. Authorisation list (Annex XIV) – indicates if the substance is included in the Authorisation List. The BPR regulatory processes identified for the Brief Profile are: Prior Informed Consent (PIC)The PIC Regulation (649/2012) entered into force on 4 July 2014. More about CAS and the CAS registry can be found here. Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram sediment (dry weight). If so, the data provided is not processed for the Brief Profile. Henry’s law constant can be presented as different types, depending on the units chosen: H dimensionless provides substance information on the substance’s Henry’s Law Constant (dimensionless) at a temperature measured in °C and a pressure measured in Pascal. This section summarises the values related to toxicity to mammals (other above-ground organisms) from all registered dossiers for the substance. This section summarises the values related to phototransformation in soil from all registered dossiers for the substance. The source of the information is mentioned in the introductory sentence of the hazard statement. If so, the data provided is not processed for the Brief Profile. The number of studies provided is indicated by ‘[x] studies submitted’, while the actual number of studies processed for the endpoint is indicated by ‘[x] studies processed’. Pimelic acid is an alpha,omega-dicarboxylic acid that is pentane with two carboxylic acid groups at positions C-1 and C-5. This section summarises the density values from all registered dossiers for the substance. Displayed is the most conservative of the prioritised value(s). The quality and correctness of the information remains the responsibility of the data submitter. Depending on the structure of the molecule the main layer may be followed by additional layers e.g. The quality and correctness of the information remains the responsibility of the data submitter. Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. If so, the data provided is not processed for the Brief Profile. Biodegradation in water - screening tests, Biodegradation in water & sediment - simulation tests. Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. Relative density at 20 °C provides information on the substance relative density at 20 °C. EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. Registrants can register their substance’s oxidising properties as: Note: Registrants can also select ‘other’ as the oxidising value for their substance. Pimelic acid is used in the manufacture of polyamides such as nylon. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Pimelic acid, also known as heptanedioic acid is a dicarboxylic acid. CAS names gives the name(s) provided to ECHA by the Chemical Abstracts Service, a division of the American Chemical Society, where available. All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. Data is generally standardised and displayed in milligram per litre/cubic metre. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). Henry’s Law Constant provides substance information on the substance’s Henry’s Law Constant measured in in Pa.m3.mol-1 at a temperature measured in °C. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. 1 000 g will be displayed as 1 kg. Registrants can choose the same picklist endpoint conclusions as mentioned under ‘Skin sensitisation’. For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. The Agency thus cannot guarantee the correctness of the information displayed. 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